G÷ 6983 1PC X 500UG

Biochem/physiol Actions

Target IC₅₀: 7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; and 60 nM for PKCζ

Reversible: yes

Primary TargetPKCα and PKCβ

Product competes with ATP.

Cell permeable: yes

General description

A potent, cell-permeable, inhibitor of protein kinase C (PKC) that has been shown to selectively inhibit several PKC isozymes (IC₅₀ = 7 nM for PKC_α and PKC_β; 6 nM for PKC_γ; 10 nM for PKC_δ; 60 nM for PKC_ζ). Gö 6983 does not effectively inhibit PKC_µ (IC₅₀ = 20 µM) and can thus be used to differentiate PKC_µ from other PKC isozymes.

A potent, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC) that inhibits several PKC isozymes (IC₅₀ = 7 nM for PKC_α and PKC_β; 6 nM for PKC_γ; 10 nM for PKC_δ; and 60 nM for PKC_ζ). Gö 6983 does not effectively inhibit PKC_µ (IC₅₀ = 20 µM) and can thus be used to differentiate PKC_µ from other PKC isozymes.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Wang, D., et al. 1998. J. Biol. Chem. 273, 33027.Stempka, L., et al. 1997. J. Biol. Chem. 272, 6805.Gschwendt, M., et al. 1996. FEBS Lett. 392, 77.

Packaging

500 µg in Plastic ampoule

Warning

Toxicity: Standard Handling (A)